Nakamura, E. et al. (2009) Accumulation of radium in ferruginous protein bodies formed in lung tissue: association of resulting radiation hotspots with malignant mesothelioma and other malignancies, Proceedings of the Japan Academy, Series B, 85, 229-239, doi: 10.2183/pjab.85.229. < 20100403102548547.admin > pub

Map on Earth or stone. Places and analyses are shown.

  • abstract:

    While exposure to fibers and particles has been proposed to be associated with several different lung malignancies including mesothelioma, the mechanism for the carcinogenesis is not fully understood. Along with mineralogical observation, we have analyzed forty-four major and trace elements in extracted asbestos bodies (fibers and proteins attached to them) with coexisting fiber-free ferruginous protein bodies from extirpative lungs of individuals with malignant mesothelioma. These observations together with patients’ characteristics suggest that inhaled iron-rich asbestos fibers and dust particles, and excess iron deposited by continuous cigarette smoking would induce ferruginous protein body formation resulting in ferritin aggregates in lung tissue. Chemical analysis of ferruginous protein bodies extracted from lung tissues reveals anomalously high concentrations of radioactive radium, reaching millions of times higher concentration than that of seawater. Continuous and prolonged internal exposure to hotspot ionizing radiation from radium and its daughter nuclides could cause strong and frequent DNA damage in lung tissue, initiate different types of tumour cells, including malignant mesothelioma cells, and may cause cancers.

  • doi: 10.2183/pjab.85.229
  • modified at 3 h ago


(a) Q-ICP-MS_procedures of Makishima and Nakamura (1997, 1999, 2006) on Q-ICPMS Agilent 7500cs
(b) MC-ICPMS on ICPMS Thermo-Fisher Element XR
(c) ICPMS with isotope dilution and internal standardization on Q-ICPMS Agilent 7500cs
(d) MC-ICPMS on MC-ICP-MS Finnigan, Neptune


(a) Q-ICP-MS_procedures of Makishima and Nakamura (1997, 1999, 2006) on Q-ICPMS Agilent 7500cs
(b) MC-ICPMS on ICPMS Thermo-Fisher Element XR
(c) ICPMS with isotope dilution and internal standardization on Q-ICPMS Agilent 7500cs
(d) MC-ICPMS on MC-ICP-MS Finnigan, Neptune


(a) Q-ICP-MS_procedures of Makishima and Nakamura (1997, 1999, 2006) on Q-ICPMS Agilent 7500cs
(b) MC-ICPMS on ICPMS Thermo-Fisher Element XR
(c) ICPMS with isotope dilution and internal standardization on Q-ICPMS Agilent 7500cs


(a) Q-ICP-MS_procedures of Makishima and Nakamura (1997, 1999, 2006) on Q-ICPMS Agilent 7500cs
(b) MC-ICPMS on ICPMS Thermo-Fisher Element XR
(c) ICPMS with isotope dilution and internal standardization on Q-ICPMS Agilent 7500cs
(d) MC-ICPMS on MC-ICP-MS Finnigan, Neptune
Img 8362@4910b56cae3a599240f8e7c thumb amosite-JAWE231 < 20130501084032-221889 >pub
  • classification: mineral
  • physical-form: powder
  • status: (unknown)
  • modified at 2019-11-05
Img 8363@18759965bcf5718c178d285 thumb crocidolite-JAWE331 < 20130501084038-562684 >pub
  • classification: mineral
  • physical-form: powder
  • status: (unknown)
  • modified at 2019-11-05
Img 8361@07dcff2ed39dce257828f0b thumb chrysotile-JAWE131 < 20130501084025-407325 >pub
  • classification: mineral
  • physical-form: powder
  • status: (unknown)
  • modified at 2019-11-05
Ti hr739578572 thumb 07-623 A < 20191025100328-813624 >pub
  • classification: biotic
  • physical-form: solution
  • quantity (g): 4.6
  • modified at 2019-11-05
Ti hr 898471311 thumb 07-787 K < 20191025101247-619732 >pub
  • classification: biotic
  • physical-form: solution
  • quantity (g): 4.0
  • description: Kobayashi
  • modified at 2019-11-05
Ti hr 498935034 thumb A-341 H < 20191025100715-633720 >pub
  • classification: biotic
  • physical-form: solution
  • quantity (g): 10.8
  • modified at 2019-11-05
Ti hr105196873 thumb 07-416 E < 20191025100547-220306 >pub
  • classification: biotic
  • physical-form: solution
  • quantity (g): 16.8
  • modified at 2019-11-05
Ti hr781586872 thumb 08-179 M < 20191025101416-585738 >pub
  • classification: biotic
  • physical-form: solution
  • quantity (g): 0.4
  • modified at 2019-11-05
Ti hr1176724665 thumb 06-0540 I < 20191025100858-686679 >pub
  • classification: biotic
  • physical-form: solution
  • quantity (g): 9.6
  • description: Ikeda Masaru
  • modified at 2019-11-05
Tixhr1854993272 thumb Ra standard, NIST SRM 4966 < 20181121162352-982131 >pub
  • physical-form: solution
  • quantity (g): 30.0
  • description: NIST SRM 4966
  • modified at 2018-11-21
name box-type global-id
binder of Accumulation of radium in ferruginous protein bodies formed in lung tissue: association of resulting radiation hotspots with malignant mesothelioma and other malignancies pub container 20191025093240-982142
name device size global-id
amosite-JAWE231 pub Q-ICPMS Agilent 7500cs 24 20191028093151-516863
amosite-JAWE231 pub Q-ICPMS Agilent 7500cs 4 20191028093842-220394
amosite-JAWE231 pub ICPMS Thermo-Fisher Element XR 14 20191028094620-085018
crocidolite-JAWE331 pub Q-ICPMS Agilent 7500cs 23 20191028093151-187331
crocidolite-JAWE331 pub ICPMS Thermo-Fisher Element XR 14 20191028094620-302348
crocidolite-JAWE331 pub Q-ICPMS Agilent 7500cs 3 20191028093842-704720
07-623 A pub MC-ICP-MS Finnigan, Neptune 1 20191028094901-597260
07-623 A pub Q-ICPMS Agilent 7500cs 24 20191028093136-326174
07-623 A pub Q-ICPMS Agilent 7500cs 4 20191028093822-601154
07-623 A pub ICPMS Thermo-Fisher Element XR 15 20191028094609-795673
07-787 K pub MC-ICP-MS Finnigan, Neptune 1 20191028095342-906479
07-787 K pub Q-ICPMS Agilent 7500cs 24 20191028093138-625291
07-787 K pub Q-ICPMS Agilent 7500cs 4 20191028093822-948207
07-787 K pub ICPMS Thermo-Fisher Element XR 15 20191028094610-578974
A-341 H pub MC-ICP-MS Finnigan, Neptune 1 20191028095127-919721
A-341 H pub Q-ICPMS Agilent 7500cs 24 20191028093137-867177
A-341 H pub ICPMS Thermo-Fisher Element XR 15 20191028094609-277562
A-341 H pub Q-ICPMS Agilent 7500cs 4 20191028093822-556900
07-416 E pub MC-ICP-MS Finnigan, Neptune 1 20191028095032-278110
07-416 E pub Q-ICPMS Agilent 7500cs 24 20191028093136-110613
07-416 E pub Q-ICPMS Agilent 7500cs 4 20191028093822-255241
07-416 E pub ICPMS Thermo-Fisher Element XR 15 20191028094609-640618
08-179 M pub MC-ICP-MS Finnigan, Neptune 1 20191028095443-380155
08-179 M pub Q-ICPMS Agilent 7500cs 4 20191028093823-025682
08-179 M pub ICPMS Thermo-Fisher Element XR 15 20191028094610-986535
08-179 M pub Q-ICPMS Agilent 7500cs 24 20191028093139-899546
chrysotile-JAWE131 pub Q-ICPMS Agilent 7500cs 24 20191028093150-357432
chrysotile-JAWE131 pub Q-ICPMS Agilent 7500cs 4 20191028093842-589073
chrysotile-JAWE131 pub ICPMS Thermo-Fisher Element XR 13 20191028094619-184853
06-0540 I pub MC-ICP-MS Finnigan, Neptune 1 20191028095234-834305
06-0540 I pub Q-ICPMS Agilent 7500cs 24 20191028093137-529522
06-0540 I pub ICPMS Thermo-Fisher Element XR 15 20191028094610-346924
06-0540 I pub Q-ICPMS Agilent 7500cs 4 20191028093822-265656
E_Dry lung pub MC-ICP-MS Finnigan, Neptune 1 20191028115211-328195
A_Dry lung pub ICPMS Thermo-Fisher Element XR 15 20191028115108-391565
M_Dry lung pub MC-ICP-MS Finnigan, Neptune 1 20191028115211-876176
K_Dry lung pub MC-ICP-MS Finnigan, Neptune 1 20191028115211-730001
I_Dry lung pub MC-ICP-MS Finnigan, Neptune 1 20191028115211-203240
H_Dry lung pub MC-ICP-MS Finnigan, Neptune 1 20191028115211-680240
H_Dry lung pub ICPMS Thermo-Fisher Element XR 15 20191028115109-112690
E_Dry lung pub ICPMS Thermo-Fisher Element XR 15 20191028115108-839134
A_Dry lung pub Q-ICPMS Agilent 7500cs 24 20191028115037-455641
M_Dry lung pub Q-ICPMS Agilent 7500cs 24 20191028115041-446405
K_Dry lung pub ICPMS Thermo-Fisher Element XR 15 20191028115109-518603
I_Dry lung pub ICPMS Thermo-Fisher Element XR 15 20191028115109-369864
H_Dry lung pub Q-ICPMS Agilent 7500cs 24 20191028115038-745743
E_Dry lung pub Q-ICPMS Agilent 7500cs 24 20191028115038-554897
A_Dry lung pub MC-ICP-MS Finnigan, Neptune 1 20191028115211-653450
M_Dry lung pub ICPMS Thermo-Fisher Element XR 15 20191028115110-312739
K_Dry lung pub Q-ICPMS Agilent 7500cs 24 20191028115040-719190
I_Dry lung pub Q-ICPMS Agilent 7500cs 24 20191028115040-350547
I_Dry lung pub Q-ICPMS Agilent 7500cs 4 20191028115154-466976
M_Dry lung pub Q-ICPMS Agilent 7500cs 4 20191028115154-195095
H_Dry lung pub Q-ICPMS Agilent 7500cs 4 20191028115153-399315
K_Dry lung pub Q-ICPMS Agilent 7500cs 4 20191028115154-401375
E_Dry lung pub Q-ICPMS Agilent 7500cs 4 20191028115153-251961
A_Dry lung pub Q-ICPMS Agilent 7500cs 4 20191028115153-402920
A_L-1 pub ICPMS Thermo-Fisher Element XR 15 20191028111532-129479
A_L-2 pub ICPMS Thermo-Fisher Element XR 15 20191028111532-005534
A_Residue pub ICPMS Thermo-Fisher Element XR 15 20191028111533-917412
A_Bulk pub ICPMS Thermo-Fisher Element XR 15 20191028111533-058907
A_L-2 pub Q-ICPMS Agilent 7500cs 4 20191028111509-171419
A_L-1 pub MC-ICP-MS Finnigan, Neptune 1 20191028112858-255287
A_Residue pub Q-ICPMS Agilent 7500cs 4 20191028111509-709863
A_Bulk pub Q-ICPMS Agilent 7500cs 4 20191028111509-646962
A_L-1 pub Q-ICPMS Agilent 7500cs 4 20191028111509-247204
A_L-2 pub MC-ICP-MS Finnigan, Neptune 1 20191028112858-738734
A_Residue pub MC-ICP-MS Finnigan, Neptune 1 20191028112858-324180
A_Bulk pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-254375
A_Bulk pub Q-ICPMS Agilent 7500cs 24 20191028111437-158354
A_L-1 pub Q-ICPMS Agilent 7500cs 24 20191028111435-410651
A_Residue pub Q-ICPMS Agilent 7500cs 24 20191028111436-798400
A_L-2 pub Q-ICPMS Agilent 7500cs 24 20191028111436-640446
E_L-1 pub ICPMS Thermo-Fisher Element XR 15 20191028111534-101011
E_L-2 pub ICPMS Thermo-Fisher Element XR 15 20191028111534-876203
E_Residue pub ICPMS Thermo-Fisher Element XR 15 20191028111534-943560
E_Bulk pub ICPMS Thermo-Fisher Element XR 15 20191028111535-534330
E_Bulk pub Q-ICPMS Agilent 7500cs 4 20191028111510-964044
E_L-1 pub Q-ICPMS Agilent 7500cs 4 20191028111509-746800
E_L-2 pub Q-ICPMS Agilent 7500cs 4 20191028111509-739802
E_Residue pub Q-ICPMS Agilent 7500cs 4 20191028111509-089052
E_L-1 pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-133084
E_L-2 pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-922089
E_Bulk pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-987701
E_L-2 pub Q-ICPMS Agilent 7500cs 24 20191028111438-026308
E_Bulk pub Q-ICPMS Agilent 7500cs 24 20191028111439-853049
E_L-1 pub Q-ICPMS Agilent 7500cs 24 20191028111437-055024
E_Residue pub Q-ICPMS Agilent 7500cs 24 20191028111438-700319
H_L-1 pub ICPMS Thermo-Fisher Element XR 15 20191028111535-904767
H_L-2 pub ICPMS Thermo-Fisher Element XR 15 20191028111536-171248
H_Residue pub ICPMS Thermo-Fisher Element XR 15 20191028111536-196781
H_Bulk pub ICPMS Thermo-Fisher Element XR 15 20191028111536-983219
H_L-1 pub Q-ICPMS Agilent 7500cs 4 20191028111510-990488
H_L-2 pub Q-ICPMS Agilent 7500cs 4 20191028111510-452739
H_Residue pub Q-ICPMS Agilent 7500cs 4 20191028111510-078354
H_Bulk pub Q-ICPMS Agilent 7500cs 4 20191028111510-420803
H_L-1 pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-330938
H_L-2 pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-546368
H_Bulk pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-408854
H_L-2 pub Q-ICPMS Agilent 7500cs 24 20191028111440-320635
H_Bulk pub Q-ICPMS Agilent 7500cs 24 20191028111441-118036
H_L-1 pub Q-ICPMS Agilent 7500cs 24 20191028111439-601096
H_Residue pub Q-ICPMS Agilent 7500cs 24 20191028111440-435106
I_L-1 pub ICPMS Thermo-Fisher Element XR 15 20191028111537-036447
I_L-2 pub ICPMS Thermo-Fisher Element XR 15 20191028111537-870980
I_Residue pub ICPMS Thermo-Fisher Element XR 15 20191028111537-634617
I_Bulk pub ICPMS Thermo-Fisher Element XR 15 20191028111538-300836
I_L-1 pub Q-ICPMS Agilent 7500cs 4 20191028111510-270807
I_L-2 pub Q-ICPMS Agilent 7500cs 4 20191028111510-406731
I_Residue pub Q-ICPMS Agilent 7500cs 4 20191028111510-396256
I_Bulk pub Q-ICPMS Agilent 7500cs 4 20191028111510-906707
I_L-1 pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-033710
I_L-2 pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-349114
I_Residue pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-514137
I_Bulk pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-320620
I_L-2 pub Q-ICPMS Agilent 7500cs 24 20191028111442-784908
I_L-1 pub Q-ICPMS Agilent 7500cs 24 20191028111442-342772
I_Bulk pub Q-ICPMS Agilent 7500cs 24 20191028111443-117898
I_Residue pub Q-ICPMS Agilent 7500cs 24 20191028111442-659603
K_L-1 pub ICPMS Thermo-Fisher Element XR 15 20191028111538-990821
K_L-2 pub ICPMS Thermo-Fisher Element XR 15 20191028111539-252404
K_Residue pub ICPMS Thermo-Fisher Element XR 15 20191028111539-535067
K_Bulk pub ICPMS Thermo-Fisher Element XR 15 20191028111539-227873
K_L-1 pub Q-ICPMS Agilent 7500cs 4 20191028111510-187069
K_L-2 pub Q-ICPMS Agilent 7500cs 3 20191028111511-189334
K_Residue pub Q-ICPMS Agilent 7500cs 4 20191028111511-590404
K_Bulk pub Q-ICPMS Agilent 7500cs 4 20191028111511-166792
K_L-1 pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-869742
K_L-2 pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-027386
K_Residue pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-362991
K_Bulk pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-400619
K_L-1 pub Q-ICPMS Agilent 7500cs 24 20191028111443-592935
K_L-2 pub Q-ICPMS Agilent 7500cs 24 20191028111444-048638
K_Residue pub Q-ICPMS Agilent 7500cs 24 20191028111444-518054
K_Bulk pub Q-ICPMS Agilent 7500cs 24 20191028111445-962060
M_L-1 pub Q-ICPMS Agilent 7500cs 4 20191028111511-803951
M_Bulk pub Q-ICPMS Agilent 7500cs 4 20191028111511-685016
M_L-2 pub Q-ICPMS Agilent 7500cs 4 20191028111511-167185
M_Residue pub Q-ICPMS Agilent 7500cs 4 20191028111511-728188
M_L-1 pub ICPMS Thermo-Fisher Element XR 15 20191028111540-852836
M_L-2 pub ICPMS Thermo-Fisher Element XR 15 20191028111540-644349
M_Residue pub ICPMS Thermo-Fisher Element XR 15 20191028111540-913143
M_Bulk pub ICPMS Thermo-Fisher Element XR 15 20191028111541-311768
M_L-1 pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-750613
M_L-2 pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-150432
M_Bulk pub MC-ICP-MS Finnigan, Neptune 1 20191028112859-400786
M_L-1 pub Q-ICPMS Agilent 7500cs 24 20191028111445-853696
M_L-2 pub Q-ICPMS Agilent 7500cs 24 20191028111446-498649
M_Residue pub Q-ICPMS Agilent 7500cs 24 20191028111446-084647
M_Bulk pub Q-ICPMS Agilent 7500cs 24 20191028111447-693974
name spots global-id
caption ID assembly stone
Data Information Table 4. Calculated elemental concentrations relative to masses of dry lung samples pub 20191028115909-111305 trace_dry (Nakamura et al., 2009) 6
Data Information Table 1. Elemental concentrations in assumed masses of asbestos body (AB) pub 20191028094018-504310 trace (Nakamura et al., 2009) 6
Data Information Table 2. Elemental concentration in asbestos standards pub 20191028094047-433740 trace_std (Nakamura et al., 2009) 3
Data Information Table 3. Analytical results of leaching experiments normalized to Fe=27 wt % pub 20191028111626-198138 trace_leaching (Nakamura et al., 2009) 24
manual
  • name
  • Nakamura, E.
  • Makishima, Akio
  • Hagino, K.
  • Okabe, K.